Time Course Data for Blood Pressure in Dahl SS and SSBN13 Rats

Salt-sensitive hypertension is known to be associated with dysfunction of the baroreflex control system in the Dahl salt-sensitive (SS) rat. However, neither the physiological mechanisms nor the genomic regions underlying the baroreflex dysfunction seen in this rat model are definitively known. Here, we have adopted a mathematical modeling approach to investigate the physiological and genetic origins of baroreflex dysfunction in the Dahl SS rat. We have developed a computational model of the overall baroreflex heart rate control system based on known physiological mechanisms to analyze telemetry-based blood pressure and heart rate data from two genetic strains of rat, the SS and consomic SS.13BN, on low- and high-salt diets. With this approach, physiological parameters are estimated, unmeasured physiological variables related to the baroreflex control system are predicted, and differences in these quantities between the two strains of rat on low- and high-salt diets are detected. Specific findings include: a significant selective impairment in sympathetic gain with high-salt diet in SS rats and a protection from this impairment in SS.13BN rats, elevated sympathetic and parasympathetic offsets with high-salt diet in both strains, and an elevated sympathetic tone with high-salt diet in SS but not SS.13BN rats. In conclusion, we have associated several important physiological parameters of the baroreflex control system with chromosome 13 and have begun to identify possible physiological mechanisms underlying baroreflex impairment and hypertension in the Dahl SS rat that may be further explored in future experimental and modeling-based investigation.

Pressure-Time series Data

The four *.txt (text) files below contain continuous blood pressure recordings for 9 Dahl SS rats and 6 Dahl SS.13BN rats, under high and low salt conditions. Read the comments at the top of each file for details.

For convenience, the data contained in the original text files are also available in standard PhysioBank format, suitable for study using the PhysioBank ATM and the WFDB Software Package. Each pair of (binary) *.dat and (text) *.hea files below comprises a PhysioBank-format record that contains data from a single rat, extracted from the *.txt files.

 Name                    Last modified      Size  Description
 Parent Directory                             -   
 DOI                     21-Sep-2015 19:00   19   
 RECORDS                 26-Jun-2012 20:07  258   list of record names
 SSBN13_HS.txt           21-Jun-2012 17:00  567K  Dahl SSBN13 on high salt diet
 SSBN13_LS.txt           21-Jun-2012 17:00  553K  Dahl SSBN13 on low salt diet
 SS_HS.txt               21-Jun-2012 16:59  844K  Dahl SS on high salt diet
 SS_LS.txt               21-Jun-2012 16:59  834K  Dahl SS on low salt diet
 local.css               28-Oct-2015 22:57  3.1K  
 ssbn13hs01.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13hs01.hea          26-Jun-2012 20:42  105   header file
 ssbn13hs02.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13hs02.hea          26-Jun-2012 20:42  105   header file
 ssbn13hs03.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13hs03.hea          26-Jun-2012 20:42  105   header file
 ssbn13hs04.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13hs04.hea          26-Jun-2012 20:42  105   header file
 ssbn13hs05.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13hs05.hea          26-Jun-2012 20:42  106   header file
 ssbn13hs06.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13hs06.hea          26-Jun-2012 20:42  105   header file
 ssbn13ls01.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13ls01.hea          26-Jun-2012 20:42  104   header file
 ssbn13ls02.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13ls02.hea          26-Jun-2012 20:42  105   header file
 ssbn13ls03.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13ls03.hea          26-Jun-2012 20:42  104   header file
 ssbn13ls04.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13ls04.hea          26-Jun-2012 20:42  105   header file
 ssbn13ls05.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13ls05.hea          26-Jun-2012 20:42  104   header file
 ssbn13ls06.dat          26-Jun-2012 20:42   23K  digitized signal(s)
 ssbn13ls06.hea          26-Jun-2012 20:42  103   header file
 sshs01.dat              26-Jun-2012 20:41   23K  digitized signal(s)
 sshs01.hea              26-Jun-2012 20:41   93   header file
 sshs02.dat              26-Jun-2012 20:41   23K  digitized signal(s)
 sshs02.hea              26-Jun-2012 20:41   93   header file
 sshs03.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 sshs03.hea              26-Jun-2012 20:42   93   header file
 sshs04.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 sshs04.hea              26-Jun-2012 20:42   94   header file
 sshs05.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 sshs05.hea              26-Jun-2012 20:42   92   header file
 sshs06.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 sshs06.hea              26-Jun-2012 20:42   93   header file
 sshs07.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 sshs07.hea              26-Jun-2012 20:42   94   header file
 sshs08.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 sshs08.hea              26-Jun-2012 20:42   93   header file
 sshs09.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 sshs09.hea              26-Jun-2012 20:42   94   header file
 ssls01.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 ssls01.hea              26-Jun-2012 20:42   91   header file
 ssls02.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 ssls02.hea              26-Jun-2012 20:42   92   header file
 ssls03.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 ssls03.hea              26-Jun-2012 20:42   92   header file
 ssls04.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 ssls04.hea              26-Jun-2012 20:42   93   header file
 ssls05.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 ssls05.hea              26-Jun-2012 20:42   92   header file
 ssls06.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 ssls06.hea              26-Jun-2012 20:42   92   header file
 ssls07.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 ssls07.hea              26-Jun-2012 20:42   92   header file
 ssls08.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 ssls08.hea              26-Jun-2012 20:42   91   header file
 ssls09.dat              26-Jun-2012 20:42   23K  digitized signal(s)
 ssls09.hea              26-Jun-2012 20:42   92   header file