Gait Dynamics in Neuro-Degenerative Disease Data Base

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Neuro-degenerative disease often affects gait and mobility. To understand better the pathophysiology of these diseases and to improve our ability to measure responses to therapeutic interventions, it may be helpful to quantify gait dynamics accurately. The records in this database are from patients with Parkinson's disease (n = 15), Huntington's disease (n = 20), or amyotrophic lateral sclerosis (n = 13). Records from 16 healthy control subjects are also included here.

The raw data were obtained using force-sensitive resistors, with the output roughly proportional to the force under the foot. Stride-to-stride measures of footfall contact times were derived from these signals, as illustrated below. (Click here for a PostScript version of this figure.)

Each of the 64 records is identified by the name of the subject group (hunt, park, als, or control) followed by an arbitrary ID number. The four files associated with each record have names beginning with the record name, and suffixes indicating the type and contents of the file:

Suffix	Contents
`.hea`	Header (text)
`.let`	Left foot signal (binary)
`.rit`	Right foot signal (binary)
`.ts`	Derived time series (text)

Within the time series (.ts) files, the contents are:

Column	Contents
1	Elapsed Time (sec)
2	Left Stride Interval (sec)
3	Right Stride Interval (sec)
4	Left Swing Interval (sec)
5	Right Swing Interval (sec)
6	Left Swing Interval (% of stride)
7	Right Swing Interval (% of stride)
8	Left Stance Interval (sec)
9	Right Stance Interval (sec)
10	Left Stance Interval (% of stride)
11	Right Stance Interval (% of stride)
12	Double Support Interval (sec)
13	Double Support Interval (% of stride)

Please note that these time series have not been filtered.

A separate file (subject-description.txt, a tab-delimited text file) includes clinical information for each subject, including age, gender, height, weight, walking speed, and a measure of disease severity or duration. For the subjects with Parkinson's disease, this is the Hohn and Yahr score (a higher score indicates more advanced disease). For the subjects with Huntington's disease, this is the total functional capacity measure (a lower score indicates more advanced functional impairment). For the subjects with amyotrophic lateral sclerosis, the number here is the time in months since the diagnosis of the disease. For the control subjects, an arbitrary 0 is used as a place holder.

Questions for study

We have done some initial analyses of these data sets. Much, however, is still unknown. For example: Are the dynamics of the sub-phases of the stride (e.g., stance and swing) identical to that of the stride itself? What is the effect of disease on gait asymmetry? Are stride dynamics nonlinear? Does this change with disease?

References

We have reported the association between disease and the dynamics of the stride time. For more information about our analyses of these data files, please see:

Hausdorff JM, Lertratanakul A, Cudkowicz ME, Peterson AL, Kaliton D, Goldberger AL. Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosis. J Applied Physiology; 88:2045-2053, 2000.
Hausdorff JM, Mitchell SL, Firtion R, Peng CK, Cudkowicz ME, Wei JY, Goldberger AL. Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington's disease. J Applied Physiology; 82:262-269, 1997.

Address for correspondence: jhausdor@caregroup.harvard.edu

 Name                    Last modified      Size  Description
 Parent Directory                             -   
 park9.rit               17-Nov-2012 21:06  132K  right foot signal
 park9.let               17-Nov-2012 21:06  132K  left foot signal
 park8.rit               17-Nov-2012 21:06  132K  right foot signal
 park8.let               17-Nov-2012 21:06  132K  left foot signal
 park7.rit               17-Nov-2012 21:06  132K  right foot signal
 park7.let               17-Nov-2012 21:06  132K  left foot signal
 park6.rit               17-Nov-2012 21:06  132K  right foot signal
 park6.let               17-Nov-2012 21:06  132K  left foot signal
 park5.rit               17-Nov-2012 21:06  132K  right foot signal
 park5.let               17-Nov-2012 21:06  132K  left foot signal
 park4.rit               17-Nov-2012 21:06  132K  right foot signal
 park4.let               17-Nov-2012 21:06  132K  left foot signal
 park3.rit               17-Nov-2012 21:06  132K  right foot signal
 park3.let               17-Nov-2012 21:06  132K  left foot signal
 park2.rit               17-Nov-2012 21:06  132K  right foot signal
 park2.let               17-Nov-2012 21:06  132K  left foot signal
 park15.rit              17-Nov-2012 21:06  132K  right foot signal
 park15.let              17-Nov-2012 21:06  132K  left foot signal
 park14.rit              17-Nov-2012 21:06  132K  right foot signal
 park14.let              17-Nov-2012 21:06  132K  left foot signal
 park13.rit              17-Nov-2012 21:06  132K  right foot signal
 park13.let              17-Nov-2012 21:06  132K  left foot signal
 park12.rit              17-Nov-2012 21:06  132K  right foot signal
 park12.let              17-Nov-2012 21:06  132K  left foot signal
 park11.rit              17-Nov-2012 21:06  132K  right foot signal
 park11.let              17-Nov-2012 21:06  132K  left foot signal
 park10.rit              17-Nov-2012 21:06  132K  right foot signal
 park10.let              17-Nov-2012 21:06  132K  left foot signal
 park1.rit               17-Nov-2012 21:06  132K  right foot signal
 park1.let               17-Nov-2012 21:06  132K  left foot signal
 hunt9.rit               17-Nov-2012 21:06  132K  right foot signal
 hunt9.let               17-Nov-2012 21:06  132K  left foot signal
 hunt8.rit               17-Nov-2012 21:06  132K  right foot signal
 hunt8.let               17-Nov-2012 21:06  132K  left foot signal
 hunt7.rit               17-Nov-2012 21:06  132K  right foot signal
 hunt7.let               17-Nov-2012 21:06  132K  left foot signal
 hunt6.rit               17-Nov-2012 21:06  132K  right foot signal
 hunt6.let               17-Nov-2012 21:06  132K  left foot signal
 hunt5.rit               17-Nov-2012 21:06  132K  right foot signal
 hunt5.let               17-Nov-2012 21:06  132K  left foot signal
 hunt4.rit               17-Nov-2012 21:06  132K  right foot signal
 hunt4.let               17-Nov-2012 21:06  132K  left foot signal
 hunt3.rit               17-Nov-2012 21:06  132K  right foot signal
 hunt3.let               17-Nov-2012 21:06  132K  left foot signal
 hunt20.rit              17-Nov-2012 21:06  132K  right foot signal
 hunt20.let              17-Nov-2012 21:06  132K  left foot signal
 hunt2.rit               17-Nov-2012 21:06  132K  right foot signal
 hunt2.let               17-Nov-2012 21:06  132K  left foot signal
 hunt19.rit              17-Nov-2012 21:06  132K  right foot signal
 hunt19.let              17-Nov-2012 21:06  132K  left foot signal
 hunt18.rit              17-Nov-2012 21:06  132K  right foot signal
 hunt18.let              17-Nov-2012 21:06  132K  left foot signal
 hunt17.rit              17-Nov-2012 21:05  132K  right foot signal
 hunt17.let              17-Nov-2012 21:05  132K  left foot signal
 hunt16.rit              17-Nov-2012 21:04  132K  right foot signal
 hunt16.let              17-Nov-2012 21:04  132K  left foot signal
 hunt15.rit              17-Nov-2012 21:04  132K  right foot signal
 hunt15.let              17-Nov-2012 21:04  132K  left foot signal
 hunt14.rit              17-Nov-2012 21:04  132K  right foot signal
 hunt14.let              17-Nov-2012 21:04  132K  left foot signal
 hunt13.rit              17-Nov-2012 21:04  132K  right foot signal
 hunt13.let              17-Nov-2012 21:04  132K  left foot signal
 hunt12.rit              17-Nov-2012 21:04  132K  right foot signal
 hunt12.let              17-Nov-2012 21:04  132K  left foot signal
 hunt11.rit              17-Nov-2012 21:04  132K  right foot signal
 hunt11.let              17-Nov-2012 21:04  132K  left foot signal
 hunt10.rit              17-Nov-2012 21:04  132K  right foot signal
 hunt10.let              17-Nov-2012 21:04  132K  left foot signal
 hunt1.rit               17-Nov-2012 21:04  132K  right foot signal
 hunt1.let               17-Nov-2012 21:04  132K  left foot signal
 control9.rit            17-Nov-2012 21:04  132K  right foot signal
 control9.let            17-Nov-2012 21:04  132K  left foot signal
 control8.rit            17-Nov-2012 21:04  132K  right foot signal
 control8.let            17-Nov-2012 21:04  132K  left foot signal
 control7.rit            17-Nov-2012 21:04  132K  right foot signal
 control7.let            17-Nov-2012 21:04  132K  left foot signal
 control6.rit            17-Nov-2012 21:04  132K  right foot signal
 control6.let            17-Nov-2012 21:04  132K  left foot signal
 control5.rit            17-Nov-2012 21:04  132K  right foot signal
 control5.let            17-Nov-2012 21:04  132K  left foot signal
 control4.rit            17-Nov-2012 21:04  132K  right foot signal
 control4.let            17-Nov-2012 21:04  132K  left foot signal
 control3.rit            17-Nov-2012 21:04  132K  right foot signal
 control3.let            17-Nov-2012 21:04  132K  left foot signal
 control2.rit            17-Nov-2012 21:04  132K  right foot signal
 control2.let            17-Nov-2012 21:04  132K  left foot signal
 control16.rit           17-Nov-2012 21:04  132K  right foot signal
 control16.let           17-Nov-2012 21:04  132K  left foot signal
 control15.rit           17-Nov-2012 21:04  132K  right foot signal
 control15.let           17-Nov-2012 21:04  132K  left foot signal
 control14.rit           17-Nov-2012 21:04  132K  right foot signal
 control14.let           17-Nov-2012 21:04  132K  left foot signal
 control13.rit           17-Nov-2012 21:04  132K  right foot signal
 control13.let           17-Nov-2012 21:04  132K  left foot signal
 control12.rit           17-Nov-2012 21:04  132K  right foot signal
 control12.let           17-Nov-2012 21:04  132K  left foot signal
 control11.rit           17-Nov-2012 21:04  132K  right foot signal
 control11.let           17-Nov-2012 21:04  132K  left foot signal
 control10.rit           17-Nov-2012 21:04  132K  right foot signal
 control10.let           17-Nov-2012 21:04  132K  left foot signal
 control1.rit            17-Nov-2012 21:04  132K  right foot signal
 control1.let            17-Nov-2012 21:04  132K  left foot signal
 als9.rit                17-Nov-2012 21:04  132K  right foot signal
 als9.let                17-Nov-2012 21:04  132K  left foot signal
 als8.rit                17-Nov-2012 21:04  132K  right foot signal
 als8.let                17-Nov-2012 21:04  132K  left foot signal
 als7.rit                17-Nov-2012 21:04  132K  right foot signal
 als7.let                17-Nov-2012 21:04  132K  left foot signal
 als6.rit                17-Nov-2012 21:04  132K  right foot signal
 als6.let                17-Nov-2012 21:04  132K  left foot signal
 als5.rit                17-Nov-2012 21:04  132K  right foot signal
 als5.let                17-Nov-2012 21:04  132K  left foot signal
 als4.rit                17-Nov-2012 21:04  132K  right foot signal
 als4.let                17-Nov-2012 21:04  132K  left foot signal
 als3.rit                17-Nov-2012 21:04  132K  right foot signal
 als3.let                17-Nov-2012 21:04  132K  left foot signal
 als2.rit                17-Nov-2012 21:04  132K  right foot signal
 als2.let                17-Nov-2012 21:04  132K  left foot signal
 als13.rit               17-Nov-2012 21:04  132K  right foot signal
 als13.let               17-Nov-2012 21:04  132K  left foot signal
 als12.rit               17-Nov-2012 21:04  132K  right foot signal
 als12.let               17-Nov-2012 21:04  132K  left foot signal
 als11.rit               17-Nov-2012 21:04  132K  right foot signal
 als11.let               17-Nov-2012 21:04  132K  left foot signal
 als10.rit               17-Nov-2012 21:04  132K  right foot signal
 als10.let               17-Nov-2012 21:04  132K  left foot signal
 als1.rit                17-Nov-2012 21:04  132K  right foot signal
 als1.let                17-Nov-2012 21:04  132K  left foot signal
 example-ts.ps           07-Nov-2000 18:13   33K  
 example-ts.png          21-Dec-2000 17:39   32K  
 hunt1.ts                07-Nov-2000 18:54   27K  time series
 park10.ts               07-Nov-2000 18:56   25K  time series
 SHA256SUMS              17-Nov-2012 21:24   24K  
 park14.ts               07-Nov-2000 18:56   24K  time series
 park2.ts                07-Nov-2000 18:55   24K  time series
 control10.ts            07-Nov-2000 18:53   24K  time series
 control9.ts             07-Nov-2000 18:53   24K  time series
 hunt9.ts                07-Nov-2000 18:54   23K  time series
 control6.ts             07-Nov-2000 18:53   23K  time series
 park6.ts                07-Nov-2000 18:55   23K  time series
 control11.ts            07-Nov-2000 18:53   23K  time series
 hunt4.ts                07-Nov-2000 18:54   23K  time series
 control4.ts             07-Nov-2000 18:53   23K  time series
 park5.ts                07-Nov-2000 18:55   23K  time series
 hunt5.ts                07-Nov-2000 18:54   23K  time series
 hunt6.ts                07-Nov-2000 18:54   23K  time series
 control8.ts             07-Nov-2000 18:53   22K  time series
 control7.ts             07-Nov-2000 18:53   22K  time series
 control1.ts             07-Nov-2000 18:53   22K  time series
 hunt12.ts               07-Nov-2000 18:55   22K  time series
 hunt8.ts                07-Nov-2000 18:54   22K  time series
 control3.ts             07-Nov-2000 18:53   22K  time series
 hunt14.ts               07-Nov-2000 18:55   22K  time series
 hunt18.ts               07-Nov-2000 18:55   22K  time series
 control13.ts            07-Nov-2000 18:53   22K  time series
 park13.ts               07-Nov-2000 18:56   21K  time series
 control5.ts             07-Nov-2000 18:53   21K  time series
 control16.ts            07-Nov-2000 18:54   21K  time series
 control14.ts            07-Nov-2000 18:54   21K  time series
 hunt17.ts               07-Nov-2000 18:55   21K  time series
 park12.ts               07-Nov-2000 18:56   21K  time series
 hunt20.ts               07-Nov-2000 18:55   21K  time series
 als10.ts                07-Nov-2000 18:52   21K  time series
 park1.ts                07-Nov-2000 18:55   21K  time series
 control12.ts            07-Nov-2000 18:53   21K  time series
 hunt19.ts               07-Nov-2000 18:55   21K  time series
 als2.ts                 07-Nov-2000 18:52   21K  time series
 control2.ts             07-Nov-2000 18:53   21K  time series
 hunt11.ts               07-Nov-2000 18:54   20K  time series
 park15.ts               07-Nov-2000 18:56   20K  time series
 hunt7.ts                07-Nov-2000 18:54   20K  time series
 als8.ts                 07-Nov-2000 18:52   20K  time series
 hunt3.ts                07-Nov-2000 18:54   20K  time series
 park3.ts                07-Nov-2000 18:55   20K  time series
 park11.ts               07-Nov-2000 18:56   20K  time series
 als11.ts                07-Nov-2000 18:52   20K  time series
 park7.ts                07-Nov-2000 18:56   19K  time series
 hunt2.ts                07-Nov-2000 18:54   19K  time series
 park9.ts                07-Nov-2000 18:56   19K  time series
 park4.ts                07-Nov-2000 18:55   19K  time series
 hunt10.ts               07-Nov-2000 18:54   19K  time series
 hunt15.ts               07-Nov-2000 18:55   19K  time series
 als3.ts                 07-Nov-2000 18:52   18K  time series
 als9.ts                 07-Nov-2000 18:52   18K  time series
 als5.ts                 07-Nov-2000 18:52   18K  time series
 park8.ts                07-Nov-2000 18:56   17K  time series
 control15.ts            07-Nov-2000 18:54   17K  time series
 SHA1SUMS                17-Nov-2012 21:24   17K  
 als1.ts                 07-Nov-2000 18:52   17K  time series
 hunt16.ts               07-Nov-2000 18:55   16K  time series
 als13.ts                07-Nov-2000 18:52   16K  time series
 als6.ts                 07-Nov-2000 18:52   15K  time series
 hunt13.ts               07-Nov-2000 18:55   14K  time series
 MD5SUMS                 17-Nov-2012 21:24   14K  
 als7.ts                 07-Nov-2000 18:52   14K  time series
 als4.ts                 07-Nov-2000 18:52   12K  time series
 als12.ts                07-Nov-2000 18:52   10K  time series
 TEST.shtml              23-Sep-2016 21:44  9.5K  
 local.css               28-Oct-2015 22:40  3.1K  
 subject-description.txt 07-Nov-2000 18:08  2.3K  clinical information
 RECORDS                 21-Dec-2000 16:52  447   list of record names
 control15.hea           17-Nov-2012 21:04  129   header file
 control4.hea            17-Nov-2012 21:04  128   header file
 control11.hea           17-Nov-2012 21:04  128   header file
 control3.hea            17-Nov-2012 21:04  127   header file
 control14.hea           17-Nov-2012 21:04  127   header file
 control12.hea           17-Nov-2012 21:04  127   header file
 control2.hea            17-Nov-2012 21:04  126   header file
 control16.hea           17-Nov-2012 21:04  125   header file
 control1.hea            17-Nov-2012 21:04  125   header file
 control7.hea            17-Nov-2012 21:04  124   header file
 control5.hea            17-Nov-2012 21:04  124   header file
 control13.hea           17-Nov-2012 21:04  124   header file
 control10.hea           17-Nov-2012 21:04  124   header file
 control9.hea            17-Nov-2012 21:04  123   header file
 control6.hea            17-Nov-2012 21:04  123   header file
 hunt13.hea              17-Nov-2012 21:04  122   header file
 control8.hea            17-Nov-2012 21:04  122   header file
 hunt12.hea              17-Nov-2012 21:04  120   header file
 park13.hea              17-Nov-2012 21:06  119   header file
 park10.hea              17-Nov-2012 21:06  119   header file
 hunt4.hea               17-Nov-2012 21:06  119   header file
 hunt20.hea              17-Nov-2012 21:06  119   header file
 hunt16.hea              17-Nov-2012 21:04  119   header file
 hunt10.hea              17-Nov-2012 21:04  119   header file
 als12.hea               17-Nov-2012 21:04  119   header file
 park8.hea               17-Nov-2012 21:06  118   header file
 park14.hea              17-Nov-2012 21:06  118   header file
 park12.hea              17-Nov-2012 21:06  118   header file
 hunt19.hea              17-Nov-2012 21:06  118   header file
 hunt18.hea              17-Nov-2012 21:06  118   header file
 hunt17.hea              17-Nov-2012 21:05  118   header file
 hunt14.hea              17-Nov-2012 21:04  118   header file
 hunt11.hea              17-Nov-2012 21:04  118   header file
 park15.hea              17-Nov-2012 21:06  117   header file
 park11.hea              17-Nov-2012 21:06  117   header file
 hunt8.hea               17-Nov-2012 21:06  117   header file
 hunt5.hea               17-Nov-2012 21:06  117   header file
 hunt15.hea              17-Nov-2012 21:04  117   header file
 als13.hea               17-Nov-2012 21:04  117   header file
 park9.hea               17-Nov-2012 21:06  116   header file
 park3.hea               17-Nov-2012 21:06  116   header file
 hunt6.hea               17-Nov-2012 21:06  116   header file
 hunt2.hea               17-Nov-2012 21:06  116   header file
 als7.hea                17-Nov-2012 21:04  116   header file
 als10.hea               17-Nov-2012 21:04  116   header file
 park6.hea               17-Nov-2012 21:06  115   header file
 park5.hea               17-Nov-2012 21:06  115   header file
 park4.hea               17-Nov-2012 21:06  115   header file
 park2.hea               17-Nov-2012 21:06  115   header file
 park1.hea               17-Nov-2012 21:06  115   header file
 hunt9.hea               17-Nov-2012 21:06  115   header file
 hunt1.hea               17-Nov-2012 21:04  115   header file
 als8.hea                17-Nov-2012 21:04  115   header file
 als11.hea               17-Nov-2012 21:04  115   header file
 als1.hea                17-Nov-2012 21:04  115   header file
 als9.hea                17-Nov-2012 21:04  114   header file
 als3.hea                17-Nov-2012 21:04  114   header file
 park7.hea               17-Nov-2012 21:06  113   header file
 hunt7.hea               17-Nov-2012 21:06  113   header file
 als5.hea                17-Nov-2012 21:04  113   header file
 hunt3.hea               17-Nov-2012 21:06  112   header file
 als6.hea                17-Nov-2012 21:04  112   header file
 als4.hea                17-Nov-2012 21:04  111   header file
 als2.hea                17-Nov-2012 21:04  111   header file
 control16.hea-          07-Nov-2000 18:54   71   header file
 control14.hea-          07-Nov-2000 18:54   71   header file
 control9.hea-           07-Nov-2000 18:53   68   header file
 control7.hea-           02-Mar-2008 15:31   68   header file
 control5.hea-           07-Nov-2000 18:53   68   header file
 control4.hea-           07-Nov-2000 18:53   68   header file
 control3.hea-           07-Nov-2000 18:53   68   header file
 control2.hea-           07-Nov-2000 18:53   68   header file
 control15.hea-          07-Nov-2000 18:54   68   header file
 control13.hea-          07-Nov-2000 18:53   68   header file
 control12.hea-          07-Nov-2000 18:53   68   header file
 control11.hea-          07-Nov-2000 18:53   68   header file
 control10.hea-          07-Nov-2000 18:53   68   header file
 control1.hea-           07-Nov-2000 18:53   68   header file
 control8.hea-           07-Nov-2000 18:53   66   header file
 control6.hea-           07-Nov-2000 18:53   66   header file
 park15.hea-             07-Nov-2000 18:56   62   header file
 park11.hea-             07-Nov-2000 18:56   62   header file
 hunt14.hea-             07-Nov-2000 18:55   60   header file
 hunt13.hea-             07-Nov-2000 18:55   60   header file
 hunt11.hea-             07-Nov-2000 18:54   60   header file
 hunt10.hea-             07-Nov-2000 18:54   60   header file
 park7.hea-              07-Nov-2000 18:56   59   header file
 park14.hea-             07-Nov-2000 18:56   59   header file
 park13.hea-             07-Nov-2000 18:56   59   header file
 park12.hea-             07-Nov-2000 18:56   59   header file
 park10.hea-             07-Nov-2000 18:56   59   header file
 hunt8.hea-              07-Nov-2000 18:54   59   header file
 hunt5.hea-              07-Nov-2000 18:54   59   header file
 hunt20.hea-             07-Nov-2000 18:55   59   header file
 hunt19.hea-             07-Nov-2000 18:55   59   header file
 hunt18.hea-             07-Nov-2000 18:55   59   header file
 hunt17.hea-             07-Nov-2000 18:55   59   header file
 hunt16.hea-             07-Nov-2000 18:55   59   header file
 hunt15.hea-             07-Nov-2000 18:55   59   header file
 hunt12.hea-             07-Nov-2000 18:55   59   header file
 als13.hea-              07-Nov-2000 18:52   59   header file
 als12.hea-              07-Nov-2000 18:52   59   header file
 als11.hea-              07-Nov-2000 18:52   59   header file
 als10.hea-              07-Nov-2000 18:52   59   header file
 park3.hea-              07-Nov-2000 18:55   57   header file
 park2.hea-              07-Nov-2000 18:55   57   header file
 park1.hea-              07-Nov-2000 18:55   57   header file
 hunt9.hea-              07-Nov-2000 18:54   57   header file
 park9.hea-              07-Nov-2000 18:56   56   header file
 park8.hea-              07-Nov-2000 18:56   56   header file
 park6.hea-              07-Nov-2000 18:55   56   header file
 park5.hea-              07-Nov-2000 18:55   56   header file
 park4.hea-              07-Nov-2000 18:55   56   header file
 hunt7.hea-              07-Nov-2000 18:54   56   header file
 hunt6.hea-              07-Nov-2000 18:54   56   header file
 hunt4.hea-              07-Nov-2000 18:54   56   header file
 hunt3.hea-              07-Nov-2000 18:54   56   header file
 hunt2.hea-              07-Nov-2000 18:54   56   header file
 hunt1.hea-              07-Nov-2000 18:54   56   header file
 als9.hea-               07-Nov-2000 18:52   56   header file
 als7.hea-               07-Nov-2000 18:52   56   header file
 als6.hea-               25-May-2004 03:56   56   header file
 als5.hea-               07-Nov-2000 18:52   56   header file
 als4.hea-               07-Nov-2000 18:52   56   header file
 als3.hea-               07-Nov-2000 18:52   56   header file
 als2.hea-               07-Nov-2000 18:52   56   header file
 als1.hea-               07-Nov-2000 18:52   56   header file
 als8.hea-               07-Nov-2000 18:52   53   header file
 DOI                     21-Sep-2015 19:00   19

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